Human papilloma virus (HPV) is carcinogenic to humans and causes cervical cancer, as well as cancers of the vagina, vulva, penis, anus and oropharynx both in men and women. Based on this evidence the vaccines against HPV have been developed, registered and a recommended for use. These include bivalent vaccine (CERVARIX), quadrivalent vaccine (GARDASIL) and nonavalent vaccine (GARDASIL9). The effectiveness and safety of these vaccines were shown in the randomized clinical trials as well as in the real life in the countries where vaccination of girls aged 12–13 years was started in 2007–8. Vaccination prevents: a) HPV infection among vaccinated, b) cervical intraepithelial neoplasia (CIN) and c) invasive cervical cancer.

World health organization (WHO) strategy to eliminate cervical cancer proposes the following targets that must be met by 2030: 90% of girls fully vaccinated by age 15; 70% women screened by 35 and again in 45 years of age. The goal of WHO is the decrease cervical cancer incidence to 4 cases per 100 000 population.

In Russia the incidence of cervical cancer is on increase since early 1990 s and further rise is predicted. Mortality from cervical cancer has slightly increased in early 1990 s and since has stabilized. In 2019 the incidence (age standardized rates) of cervical cancer was 15,4 and mortality 5,6 per 100 000 population. The number of newly diagnosed cases was 17 500 and amount of dearth from cervical cancer – 6300.

In this paper we assess the number of the preventable cervical cancer cases and death from this disease in women aged 15–79 years during the forthcoming years of 21 century as a result of the HPV vaccination of girls born in 2009–2018, 2019–28, 2029–2038. The prognosis is based on the incidence and mortality from cervical cancer in 2018 and predicted rates for 2032. Our assumption was that of 90% of girls under 15 years will be covered by vaccination and the effectiveness of vaccination will be 79,80% in decrease of the HPV prevalence.

The estimates based on 2018 statistics suggest that among women born in 2009–2038 years – 348 850 will be diagnosed with cervical cancer and 117 862 will die from it. The timely vaccination of 90% of girls will prevent 250544 cases and 84648 deaths from cervical cancer. Based on the estimated incidence and mortality for 2032 among these cohorts of women 470 729 will be diagnosed with and 130 811will die from cervical cancer. vaccination will prevent 338 078 cases of disease and save 93 948 lives.

We have shown that vaccination results in the decrease in incidence and mortality from cervical cancer and will save hundred thousands of lives. This is the strongest argument for urgent implementation of vaccination program in Russia. An additional important task is the assessment of economic impact of vaccination in comparison with the heavy burden imposed by disease and deaths from cervical cancer. The financial losses due to high incidence and mortality from cervical cancer or any other disease in addition to the costs of treatment include demographic and social factors. The latter will have largest impact on the economy and wellbeing of the country.

Therefore the next step of our study will be the analyses of the cost-effectiveness of HPV vaccination in the cohort of 24 million women born in 2009–2038 based on the predicted in this paper incidence and mortality of cervical cancer and number of disease and deaths that will be prevented by vaccination.

Purpose: assess changes in the health state of teenage-youth due to the transformation of the sociocultural environment (on the example of the Irkutsk region).

Materials and methods. The observation contingent is the population of adolescence (15–19 years old). The subject of the study is the characteristics of the incidence and mortality of the contingent underline in the process of changes in the sociocultural medium. Data on mortality rates were obtained on sites of Federal State Statistics Service and of the Center for Demographic Research of the New Economic School, the trend analysis was carried out by a linear regression analysis using the SPSS program (IBM).

Results. In the first half of the post-Soviet period (from 1991 to 2005–2009), in the Irkutsk region, in the contingent of adolescence, there was a rapid increase in the prevalence of some socially determined diseases and states (addiction, sexually transmitted diseases), as well as mortality rates. In the second half of the period (from 2006–2010 to 2020), there was a decrease in morbidity and mortality, however, with all positive shifts, even the relative well-being in these areas was not achieved. In 2019, the mortality rates of young men in connection with suicides in the region exceeded the corresponding figures of Poland 2,5 times, Sweden – 8,2 times; Mortality rates from violent causes (murders) exceeded the corresponding figures of Poland 6,4 times, Sweden – 2,0 times. High levels of socially determined morbidity, adolescence mortality in the post-Soviet period are a consequence of adverse changes in the sociocultural environment.

Conclusion. Negative phenomena in the mentally-psychological and somatic health of young people are developing in a state of culture, characterized as “sociocultural destruction”. The latter is due to the processes of marginalization of the population, miscalculations in the areas of state ideology and cultural policies, the destruction and substitution of value orientations, the degradation of morality. The most important task facing the authorities and society is to overcome the factors leading to socio-cultural destruction, strengthening the integrity of the consolidating ethnic group of the cultural system.

The fight against the COVID‑19 pandemic has led to the implementation of unprecedented measures in countries, including self-isolation, which have had a significant impact on people’s behavior and could lead to a change in the consumption of tobacco and nicotine-containing products. This article provides an overview of studies evaluating smoking behavior change and its impact on the prevalence of tobacco and nicotine use in the community at the start of the pandemic.

Methods. The review included 31 published studies with data on smoking from more than 250,000 people from 24 countries that examined the following aspects of the problem: the association of smoking with COVID‑19 outcomes, identification of factors influencing smoking behavior at the beginning of the COVID‑19 pandemic, changing prevalence of tobacco and nicotine consumption at the start of the COVID‑19 pandemic, tobacco company actions during the pandemic, impact of misinformation about the association of smoking with COVID‑19 on consumers of tobacco and nicotine products, government actions to reduce the sale of tobacco and nicotine products during the pandemic time.

Findings. All researchers identified mixed responses from consumers of tobacco and nicotine-containing products early in the pandemic. In equal proportions, smokers increased their tobacco/nicotine intake or reduced their smoking intensity. To a lesser extent, consumers quit smoking, but there were respondents who reported starting smoking due to the COVID‑19 pandemic.

Conclusion. Monitoring the prevalence of consumption of tobacco and nicotine-containing products and the causes influencing it in the early periods of the COVID‑19 pandemic made it possible to identify additional effective measures, the implementation of which can prevent the growth of tobacco and nicotine consumption in such situations.

I n t r o d u c t i o n . Non-psychotic mental disorders are most prevalent mental disorders with the high relapse rate and onset in the early adulthood the most active period of life, psychosocial factors play essential role in their ethiopathogenesis. Psychotherapy as method influencing one’s mind and through the mind affecting ones organism is considered to play an essential role in the treatment system of this patients group as well as in medico-psychological support of the patients with somatic illnesses.

Obj e c t i v e definition of the modern psychotherapy content as independent medical specialty based on the modern data base of its efficacy research systematization, evaluation of its further perspectives development for the provision of the healthcare for the targeted population of the patients with non-psychotic mental disorders as well as organization of the medico-psychological support for the patients with somatic illnesses, taking into account the possibilities offered by digital technologies

М e t h o d s . WHO, PubMed, Scopus, Pubmed, Medline, Web of Science, Russian Science citation index Science Citation Index search was conducted on non-psychotic mental disorders epidemiology, COVID-19 pandemic impact on mental health, psychotherapy efficacy and psychotherapeutic treatment settings, possibilities of digital technologies implementation in modern psychotherapy.

R e s u l t s . The prevalence of non-psychotic mental disorders is constantly growing in the las years, they make a serious impact in the non-communicable diseases burden, with the increase of the treatment costs. The COVID-19 pandemic is characterized by decrease of mental health well-being, growth of the anxiety and depressive disturbances, also because of the somatogenic disorders included in the post-covid syndrome.

The recent studies persuasively demonstrated the efficacy of psychotherapy in the non-psychotic mental disorders treatment, combination of psycho- and pharmacotherapy is defined as the golden standard treatment, the ratio of them should be determined personalized in each individual case. Digital technologies active development, computerized psychotherapeutic programs implementation open new possibilities for the research of the psychotherapeutic treatment mechanisms as well as make psychotherapy more available for the different population groups and can substantially decrease treatment costs in the future.

Mental health care provision optimization should be aimed at the greater psychotherapists involvement as the main specialists for diagnostic and complex treatment of non-psychotic mental disorders treatment, development of psychotherapeutic offices network, they could be a center of this patient group healthcare system, as well as for patients recovering from novel coronavirus infection with psychoneurological complains, and can be used for the medico-psychological support of the patients with somatic illnesses.

Conclusion. Psychotherapy today is recognized as an effective non-psychotic mental disorders treatment method, in the future it can be used as an epigenetic modulator in the personalized medicine framework, it can be considered as an essential part of the medical-psychological support of the patients with somatic illnesses.

The purpose of this article is to analyze the socio-economic aspects of public health in the context of the costs and benefits of modern enterprise. As a key characteristic of labor resources, public health significantly affects the pace and quality of socio-economic development. In the modern economy, public health is on a par with such system-forming characteristics of the labor force as education, qualifications, creativity, and is increasingly trying on the role of the leading factor in economic growth. The article provides evidence that concern for the health of personnel should act as a burden on owners and managers, relying on formal (by the state) and informal (by public opinion) norms that oblige entrepreneurs to take on a certain amount of responsibility in relation to its personnel in terms of employee insurance; ensuring proper working conditions, labor protection, etc.; formation of a health fund; creation of medical structures. Along with this, we record a number of benefits arising from this, including retention of personnel, the formation of a stable and interested core of the labor collective, stability, loyalty of the labor collective, a reduction in the number of absences due to illness, increased efficiency, an increase in the number of so-called innovative “smuggling” projects, the demonstration effect of moral standards.

The purpose of the research is to systematize the problems of the branch, formulate goals and objectives, search for methods and software and organizational solutions for digital medicine. Applied systems analysis, software engineering and artificial intelligence methods are used as research methods. The result of the research is the digital platform “Health History”, an organizational and technical system, which is a working prototype of a system solution for the reorganization of processes. The conclusion is postulated about the need for fundamental organizational changes in medicine based on information technologies, which is the essence of the digital transformation of healthcare.